A couple of months ago, I stopped taking Prozac. Then came the diminished sex drive and difficulty getting an erection or having an orgasm. Fluoxetine can have side-effects that might affect your sex life. The good effects of fluoxetine may, after a while, have a good effect on your sex life as your mood lifts and you become interested in life and relationships again. Some of the possible negative side effects include: You may have a lower sex drive.